ADME DB
The Online Bio Database service aims to provide information in areas ranging from biology to computer chemistry. The currently available database is ADME Database version - a database of substrates, inhibitors, inducers and activators of Drug Metabolizing Enzymes and Drug Transporters.
Human P450 Metabolism Database
Provides information on 50 CYP enzymes and a number of variants, which participate/are tested in the metabolism of xenobiotics and endobiotics in humans.
- Contains over 13 000 entries
- Contains more than 6 500 substances, a number of natural products and preparations, as well as other factors influencing CYP activity
- Contains data collected from more 3 000 citations
Other Enzymes
The information on the following enzymes are currently available: Esterase, UDP-glucuronosyltransferase, Sulfotransferase, Glutathione S-transferase.
| Drug Metabolizing Enzymes |
# of Entries |
| Substrate |
1,259 |
| Inhibitor |
602 |
| Inducer |
1 |
Kinetic Metabolism Database
- Database contains over 11,000 entries extracted from Human Cytochrome P450 metabolism database references providing numerical data on major kinetic parameters relevant for use in drug developing/application studies
- Human P450 Kinetic Database is available only when it is coupled with Human P450 Database
Human Transporters Database
- Provides information on more than 256 Transporters involved in drugs transport, physiological compounds, nutrients, and other chemicals and metabolites
- ABC Transporter
- Organic Ion Transporter
- Peptide Transporter
- Nucleotide Transporter etc.
Available Information
Detailed information for each entry includes the following data items:
- Protein information about either P450/Transporter
- Metabolic Reaction*
- Interaction Type (substrate, inhibitor, inducer, activator)
- Drug/Metabolite* structure
- References
- Links to PUBMED
Note:Included only in Human P450 Database
P450 Kinetic Information
Kinetic information for each entry includes the following data items:
- Michaelis - Menten Constant (Km)
- Maximum Velocity Vmax
- Inhibition Constant Ki
- Cooperativity
- Half-life of drug elimination T_half
- in vitro Assay Model used to determin the kinetic parameters
Summary Information
- The information summarized for each entry is shown in tabular format
- Results may be sorted to allow you to identify compounds of interest
Advantages
- Reduce the costs
Since the service is available online, it is accessible anywhere via a web browser. As a result, there is no need to pay for expensive initial cost associated with a package software.
- Instant access
Upon subscription and receiving a user ID and a password, users are able to login to the system on a 24×7 operating basis throughout the entire year (excluding system maintenance periods).
- No maintenance/management fees
There is no need to setup a dedicated server within the company. This eliminates the need for maintenance, management, regular data backups, and updates.
- High security
With Fujitsu's high security measures being implemented, there is no need to worry about data loss and information leaks.
